MRC-NHS Call for Proposals: Efficacy and Mechanism Evaluation Programme

Deadline: 4 July 2017

The Efficacy and Mechanism Evaluation (EME) Programme is currently seeking proposals for hypothesis driven research into the underlying mechanisms of action of clinical and public health interventions. Studies must utilise patients or samples from identifiable cohorts from current or completed NIHR-funded or NIHR-managed studies in any setting.

Proposals will be accepted across a wide range of interventions; including behavioural, pharmaceutical, psychological, surgical and public health interventions. The research should be hypothesis driven, relevant to the intervention and outcomes proposed by the original study and add significantly to the scientific understanding of the mechanisms of action of the intervention.

Funding Criteria

The EME Programme will support:

  • Research to determine proof of clinical efficacy, size of effect, and long-term safety in a well-defined population.
  • The evaluation of a broad range of interventions that have the potential to maintain health, treat disease or improve recovery.
  • Hypothesis-testing research based on an efficacy study, to explore the mechanisms of action of interventions, causes of differing responses or disease mechanisms. These studies use data or samples obtained and stored from both treatment and control groups of a clinical study, to arrive at conclusions that would not arise from a simple cohort study.
  • Proposals that include a series of linked stages (usually 2 to 3) with progression to the main clinical evaluation dependent on the outcome of the previous stage(s). The criteria for progression must be clearly defined.  The main clinical evaluation should require more than 75% of the total project costs and commence within 18 months of the project start date.
  • Pilot and feasibility studies where the main study would be within the remit of the EME Programme. These studies may be either stand-alone or can be the initial part of a staged project that includes the main clinical evaluation as a subsequent stage.
  • The limited steps needed to progress the development of an intervention to a stage suitable for use in an accredited clinical service when included as an initial stage prior to commencing the main clinical evaluation.
  • Studies using novel or infrequently-used study designs that increase the value of a study, by maximising the chances of demonstrating the benefit of an intervention, increasing the knowledge that can be gained through the study, or by making the study more efficient.

Eligibility Criteria

  • Researchers in England, Northern Ireland, Scotland and Wales are eligible to apply for funding under this Programme. Anyone who considers that they can carry out high-quality research is likely to be eligible. If you have any concerns regarding your eligibility to apply we advise that you contact us before completing an application. Applications are accepted from all sectors.
  • Studies funded by the EME Programme are generally UK based.

How to Apply

Applications must be submitted in a prescribed format via given website.

Eligible Country: UK

For more information, please visit MRC-NHS Call for Proposals.

NERC: Human-Environment Interactions & the Sustainable Development Goals

D4D Call for Proposals: Improving Socio-Economic Opportunities and Perspectives for Women and Men in BiH

Embassy of Japan in Sudan: Grant Assistance for Grassroots and Human Security Projects (GGP) 2018

U.S. Department of State’s Bureau of NEA/AC: Promoting the eSports Industry in the MENA Region

Robert Carr Fund for Civil Society Networks: 2018 Request for Proposals (RFP)

APS-MSI: Inviting Applicants for Afghanistan’s Measure for Accountability and Transparency (AMANAT) Project

IWPR Call for Applications: Project Sub-grants for Ukrainian Activists and Journalists

RECP Finance Catalyst: Targeting Small and Medium Scale Renewable Energy Projects

Healthcare Georgia Foundation: Seeking Applications for 2018 Direct Services Grant Program

IDRC/CIHR/SSHRC Call for Research Proposals: Rapid Research Fund for Ebola Virus Disease Outbreaks

Empowers Africa: Grants to Support Human Empowerment, Wildlife Protection and Land Conservation

U.S. Mission to Moldova: Seeking Applications for American Resource Center (ARC) PRogram

Apply for WWF-India’s Small Grants Innovation Program!

Inspirit Foundation: Inviting Applicants for Core Grants

Applications Open for Lottery Environment and Heritage Grant Program!

SABI Grants Fund: Inviting Sierra Leone based NGOs & CSOs

Heritage Lottery Fund: Seeking Applications for Heritage Grants Programme

Shell Canada Grant Program: Social Investment in Communities throughout Canada

SSRC Call for Proposals: Political Institutions and Challenges to Democracy

Call for Concept Proposals: GEF Small Grants Programme

SNSF Call for Proposals: Inviting Applications for Southeast Asia-Europe Joint Funding Scheme

Third Wave Fund: Seeking Applications for Mobilize Power Fund

EPA Green Enterprise 2018: Innovation for a Circular Economy Programme

British Embassy in Ankara: Seeking Project Proposals for British Embassy Programme Fund