The Department of Health and Human Services and National Institutes of Health is pleased to announce a call for proposals to Addressing Social Determinants of Health to Eliminate Oral Health Disparities to support research on how to optimally address upstream social determinants of health that can often present a barrier to optimal oral health and impede the effectiveness of clinical interventions, particularly in vulnerable and underserved communities.
This initiative will encourage multi-disciplinary collaborations, mechanistic research, multi-level research, and the use of complex systems science approaches.
Specific areas of research interest may include, but are not limited to:
- Elucidating mechanisms and causal pathways between SDOH and oral health outcomes across multiple socioecological levels.
- Conducting multi-level interventions that incorporate addressing SDOH as part of the overall intervention to improve oral health outcomes.
- Conducting interventions that address SDOH related to structural racism in settings where oral health care is delivered across multiple domains (e.g. provider-patient interactions, service delivery, access to care, etc.) to improve oral health outcomes and reduce disparities.
- Leveraging strategies or conducting interventions that integrate oral health into primary care, non-health sectors, or community-based settings to address SDOH and improve oral health outcomes.
- Demonstrating the use of non-traditional healthcare practitioners (e.g. social workers or case managers) to promote oral health and address SDOH barriers.
- Demonstrating the use of technology, including electronic health records, mobile health technologies, smart devices, or sensors to address SDOH barriers and improve oral health, without exacerbating health disparities.
- Utilizing SMSS approaches to identify modifiable SDOH barriers across various sectors (e.g., food access, transportation, healthcare) and provide evidence-based simulation or prediction of the impact of effective interventions delivered in real-world settings to address these barriers to improve oral health outcomes.
- Utilizing SMSS approaches involving big data or other appropriate data sources to elucidate etiology and complex interrelationships between different SDOH, and causal pathways by which they lead to oral health disparities and provide targets for population-based interventions.
- Planning Phase (UG3): The UG3 award will provide one year of support for planning activities, such as finalizing the protocol and preparing other documents or required data sources to implement the full study. Additional planning activities are allowable, such as evaluating the number of participants at a site who would fulfill eligibility criteria, data collection or intervention delivery for the purpose of user acceptance testing, establishing acceptability and feasibility of the study procedures, and/or study intervention delivery/fidelity monitoring. The UG3 phase cannot be used to test for intervention efficacy. Examples of activities supported during the UG3 phase include, but are not limited to, developing the following:
- A final clinical protocol, prepared using the standard NIDCR observational or interventional protocol template that is ready for submission to the central IRB;
- Successful preparation of the manual of procedures, quality management plan, and data management plan, as applicable;
- Finalization of all documents necessary to implement the full study (e.g., case report forms, etc.);
- Consent form(s) and, if applicable, assent form(s);
- A final statistical analysis plan;
- A plan to administer study intervention, train interventionalists, and monitor intervention delivery, for clinical trials;
- A recruitment/enrollment and retention plan for the clinical study; and
- Obtainment, quality review, assurance of data harmonization and interoperability, and preparation of all data sources for proposed SMSS or data science-focused studies.
- Implementation Phase (UH3): The UH3 award will provide up to five years of support to conduct the full study in accordance with activities planned in the UG3 phase, and is contingent upon successful completion of the UG3 milestones. NIDCR expects studies supported during the UH3 phase to be hypothesis driven and have defined milestones. UH3 activities may include the following operational activities, expressed as UH3 milestones:
- Completion of data management system(s)
- Completion of regulatory approvals
- Study activation
- Registration of clinical trial in ClinicalTrials.gov (for clinical trials)
- Enrollment of the first subject for studies with prospective enrollment
- Enrollment and randomization, if applicable, of 25%, 50%, 75% and 100% of the projected study population for studies with prospective enrollment
- Completion of data collection for studies with prospective enrollment
- Completion of primary outcome data analyses
- Reporting of results in ClinicalTrials.gov (for clinical trials)
- Funds Available and Anticipated Number of Awards: NIDCR intends to commit $3 million in FY 2022 to fund 3-4 awards, contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
- Award Budget: Application budgets are limited to less than $300,000 in direct costs for the UG3 phase; Application budgets are not limited for the UH3 phase, but need to reflect the actual needs of the proposed project.
- Award Project Period: The total project period may not exceed one year for the UG3 phase and five years for the UH3 phase.
- Higher Education Institutions
- Public/State Controlled Institutions of Higher Education
- Private Institutions of Higher Education
- The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
- Nonprofits Other Than Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- For-Profit Organizations
- Small Businesses
- For-Profit Organizations (Other than Small Businesses)
- Local Governments
- State Governments
- County Governments
- City or Township Governments
- Special District Governments
- Indian/Native American Tribal Governments (Federally Recognized)
- Indian/Native American Tribal Governments (Other than Federally Recognized)
- Federal Governments
- Eligible Agencies of the Federal Government
- U.S. Territory or Possession
- Independent School Districts
- Public Housing Authorities/Indian Housing Authorities
- Native American Tribal Organizations (other than Federally recognized tribal governments)
- Faith-based or Community-based Organizations
- Regional Organizations
For more information, visit https://www.grants.gov/web/grants/view-opportunity.html?oppId=333169