Deadline: 05-Dec-2025
The CART Fund is inviting interested applicants from within the United States only to submit a Letter-of-Intent (LOI) that includes sufficient detail to communicate the importance of your study as well as information on its feasibility.
The goal of CART is to encourage exploratory and developmental Alzheimer’s Disease (AD) research projects within the United States by providing support for the early and conceptual plans of those projects that may not yet be supported by extensive preliminary data but have the potential to substantially advance biomedical research.
This proposal should be distinct from those projects designed to increase knowledge in a well-established area unless it is intended to extend previous discoveries toward new directions or applications. Applications may encompass a project period of up to two years with a combined budget for direct costs up to $500,000. No indirect costs are allowed.
Full-time faculty (or the equivalent status) at U.S.-based public and private institutions, such as universities, colleges, hospitals, and laboratories, are eligible. This is for new projects only. Applications will be deemed ineligible from for-profit and organizations outside of the United States, as well as those already supported by regular or program grants.
A scientific review group will triage the letters-of-intent and select a maximum of 15 finalists deemed to have the highest merit. Those selected will be invited to submit a subsequent standard grant application from which the final recommendations will be made by the review group. The final selections will be made by the CART Fund Grant Selection Committee.
Applicants should submit a letter-of-intent as a PDF file. The letter should include the following: contact information with a one-page limit; a statement containing the hypothesis of the project, the specific aims, and a description of the experimental design, methods, and model systems with a two-page limit; a statement giving future directions this research could lead to, including a reference to the health relationship of the project with a half-page limit; a biographical statement of the principal investigator with a two-page limit; a publication list of the principal investigator with a two-page limit; and references with a one-page limit.
Applicants will be notified via email of the finalists selected for further review by January 9, 2026. Finalists must submit their full grant applications by February 13, 2026, and the notification of final selections will be made on March 31, 2026.
The submission deadline for letters of intent is December 5, 2025.
For more information, visit The CART Fund.