Deadline: 7-Sep-24
The Department of Health and Human Services and National Institutes of Health is seeking applications from investigators interested in conducting basic, mechanistic research into the biological/genetic causes of cancer health disparities.
The projects should propose innovative studies designed to investigate biological/genetic bases of cancer disparities, such as:
- mechanistic studies of biological factors associated with cancer disparities, including those related to basic research in cancer biology or cancer prevention strategies,
- the development and testing of new methodologies and models, and
- secondary data analyses.
This Funding Opportunity Announcement (FOA) is also designed to aid and facilitate the growth of a nationwide cohort of scientists with a high level of basic research expertise in cancer health disparities research who can expand available resources and tools, such as biospecimens, patient derived models, and methods that are necessary to conduct basic research in cancer health disparities.
Topics of Interest
Research topics of interest include but are not limited to:
- Causal drivers of early onset of certain cancer types in specific populations
- Genetic/epigenetic mechanisms of cancer susceptibility differences among racial/ethnic populations, such as epigenetic drivers and or suppressors
- Understanding how race/ethnicity impacts disease penetrance in individuals who inherit a cancer susceptibility gene
- Understanding if race/ethnicity has a role in regression of precancerous lesions
- Understanding if risk factors, including environmental exposures, differ across race/ethnicity to influence development of precancerous lesions
- Identifying cancer risk and early detection biomarkers among underrepresented populations
- Examination of how stress impacts the progression of symptoms across different population groups
- Identify underlying mechanisms of symptoms that are responsible for altering treatment regimens that increase the risk of mortality for racial/ethnic minority patients with cancer
- Understand the process through which precision therapies improve symptom management to reduce health disparities
- Similarities and differences in cancer metabolism (e.g. alterations in metabolic fuel sources, fatty acid synthesis, lipid metabolism, glycolysis, nutrient uptake) among racial/ethnic populations
- New 3D cellular models, organoids, xenografts, patient-derived models and microfluidic systems designed to recapitulate and investigate cancer disparities
- Epithelial and mesenchymal markers in circulating tumor cells in cancer patients of distinct racial/ethnic groups
- Investigations of how social health disparities may cause adverse gene expression that confers increased cancer risk and/or aggressiveness
- Role of the microbiota in cancer health disparities during tumorigenesis and cancer progression
- Role of the oncogenic pathogens in the development of cancer health disparities during tumorigenesis and cancer progression, in population groups
- Computational analysis and modeling for predicting aggressive tumors in distinct racial/ethnic populations
- Understanding the biologic mechanisms behind the differences in toxicity and symptoms seen in various racial/ethnic population during cancer treatment
- Understanding of biological mechanisms of how stress impacts the progression of symptoms in different population groups
- Deciphering the mechanisms of accumulated exposure to environmental toxins across populations groups
- Understanding the biological processes through which precision interventions improve symptom management to reduce cancer health disparities
- Biological bases of differences among racial/ethnic populations in responses to cancer immunotherapies and/or development of immune-related adverse events induced by cancer immunotherapies.
Funding Information
- Award Budget: Application budgets are limited to $50,000 in direct costs per year.
- Award Project Period: The total project period may not exceed 2 years.
Eligibility Criteria
- Higher Education Institutions
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- Public/State Controlled Institutions of Higher Education
- Private Institutions of Higher Education
- The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
- Nonprofits Other Than Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- For-Profit Organizations
- Small Businesses
- For-Profit Organizations (Other than Small Businesses)
- Local Governments
- State Governments
- County Governments
- City or Township Governments
- Special District Governments
- Indian/Native American Tribal Governments (Federally Recognized)
- Indian/Native American Tribal Governments (Other than Federally Recognized)
- Federal Governments
- Eligible Agencies of the Federal Government
- US Territory or Possession
- Other
- Independent School Districts
- Public Housing Authorities / Indian Housing Authorities
- Native American Tribal Organizations (other than Federally recognized tribal governments)
- Faith-based or Community-based Organizations
- Regional Organizations
- Non-domestic (non-US) Entities (Foreign Institutions)
For more information, visit https://www.grants.gov/web/grants/view-opportunity.html?oppId=335544