Deadline: 06-Dec-21
The Department of Health and Human Services (DHHS) and National Institutes of Health (NIH) has announced this Funding Opportunity to investigate innate immune cell effector functions and innate immune memory as a means to prevent HIV infection and/or establishment of disease.
Exploratory research from basic molecular mechanisms, translational work, and clinical research examining innate memory are encouraged.
Objectives
- There is a paucity of data on innate immune memory in general and in the context of HIV specifically.
- Addressing this gap is critical to inform and design protective vaccine strategies that will engage, enhance, and extend innate immune cell effector functions without causing harm.
- Key scientific questions include:
- Does HIV exposure or infection induce innate immune memory?
- What mechanisms regulate innate immune memory which impact HIV acquisition?
- Can innate memory functions be augmented for more effective HIV vaccination/control strategies?
- The primary objective of this funding opportunity is to support exploratory research that will identify basic mechanisms of innate antiviral cell effector functions in the context of HIV, as well as to explore innovative strategies that exploit innate immune cells to prevent acquisition or establishment of HIV infection.
- Recent advances in ‘omics’ and EpiTOF/ATAC-Seq technologies, availability of samples from unique human cohorts and clinical studies, and appropriate animal models, could contribute to answering these questions.
Funding Information
- Funds Available and Anticipated Number of Awards: NIAID and partner components intend to commit an estimated total of $2,500,000 to fund 7-8 awards, for fiscal year 2022.
- Award Budget: The combined budget for direct costs for the two-year period may not exceed $275,000. No more than $200,000 may be requested in any single year.
- Award Project Period: The total project period may not exceed two years.
Eligibility Criteria
- Higher Education Institutions
- Public/State Controlled Institutions of Higher Education
- Private Institutions of Higher Education
- The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
- Nonprofits Other Than Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- For-Profit Organizations
- Small Businesses
- For-Profit Organizations (Other than Small Businesses)
- Local Governments
- State Governments
- County Governments
- City or Township Governments
- Special District Governments
- Indian/Native American Tribal Governments (Federally Recognized)
- Indian/Native American Tribal Governments (Other than Federally Recognized)
- Federal Governments
- Eligible Agencies of the Federal Government
- U.S. Territory or Possession
- Other
- Independent School Districts
- Public Housing Authorities/Indian Housing Authorities
- Native American Tribal Organizations (other than Federally recognized tribal governments)
- Faith-based or Community-based Organizations
- Regional Organizations
- Non-domestic (non-U.S.) Entities (Foreign Institutions)
For more information, visit https://www.grants.gov/web/grants/view-opportunity.html?oppId=334613