Deadline: 21-Oct-22
The Department of Health and Human Services, National Institutes of Health (NIH) solicit applications for Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT) Centers.
The overall goal of the CAP-IT Program is to establish an agile and effective network infrastructure to undertake collaborative research focusing on precision cancer prevention and interception, with the overarching goal of discovering molecularly or immunologically targeted agents designed to prevent or intercept the oncogenic process in higher-risk populations.
Objectives
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To achieve the Program's overarching goal which is to discover molecularly or immunologically targeted agents designed to prevent or intercept the oncogenic process for precision cancer prevention and interception, CAP-IT research objectives are as follows:
- To identify targets that can be potentially exploited for cancer preventive or interceptive interventions specifically in higher-risk populations, by collaborating with the NCI and other programs with a research focus on molecular profiling of precancer, early cancer, and/or oncogenic signaling pathways, and prioritize high-value oncotargets for the discovery of targeted interventions;
- To functionally validate the critical roles of the high-value oncotargets in tumor initiation and/or progression to invasive cancer and select oncotargets suitable for targeted intervention strategies; and
- To discover innovative targeted agents through in vitro and in vivo efficacy evaluation and advance promising efficacious agents to the NCI's existing R&D pipeline for further development.
Funding Information
- Award Ceiling: $720,000.
Activities
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CAP-IT Trans-Network Activities applicable to the CAP-IT Centers will include but are not limited to:
- Interacting with the CAP-IT DRCC to establish a centralized CAP-IT database for in-network data archiving and sharing in accordance with the policies established by the CAP-IT SC;
- In-network sharing of research tools and resources, such as novel assay technologies, protocols, preclinical biospecimens and agents developed through the conduct of CAP-IT research in accordance with the policies established by the CAP-IT SC;
- Coordinating, facilitating, and participating in network-wide meetings, such as an Annual CAP-IT Investigators’ Meeting, workshops, seminars and CAP-IT SC meetings.
Eligibility Criteria
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Eligible Organizations
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Higher Education Institutions
- Public/State Controlled Institutions of Higher Education
- Private Institutions of Higher Education
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The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
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Nonprofits Other Than Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
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For-Profit Organizations
- Small Businesses
- For-Profit Organizations (Other than Small Businesses)
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Local Governments
- State Governments
- County Governments
- City or Township Governments
- Special District Governments
- Indian/Native American Tribal Governments (Federally Recognized)
- Indian/Native American Tribal Governments (Other than Federally Recognized)
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Federal Governments
- Eligible Agencies of the Federal Government
- U.S. Territory or Possession.
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Higher Education Institutions
For more information, visit Grants.gov.
For more information, visit https://www.grants.gov/web/grants/view-opportunity.html?oppId=343505