Deadline: 16-Jan-23
The National Institutes of Health (NIH) invites grant applications that seek to advance or clinically validate emerging novel approaches for the development of safe, real-time, non-invasive (or minimally invasive) methods to assess the development and function of the human placenta across pregnancy.
Scope of Research to be Performed
- This FOA is for the advancement of novel methods for assessing the placenta’s real time in vivo status with the ultimate goal of human use across pregnancy. Special consideration will be given to applications that develop methods that are applicable throughout pregnancy, preferably starting in early gestation during the period of trophoblast invasion and remodeling of the uterine spiral arteries, and which facilitate assignment of relative risk for pregancy complications.
- The placenta is a dynamic organ which changes over the course of pregnancy. To be helpful, assessments need to yield results within a time frame that reflects the current structural/functional status. However, real-time is not meant to imply instantaneous results.
Priorities
Projects that are considered low priority for this FOA include:
- Development of technologies that can only be applied in the third trimester of pregnancy or postpartum.
- Projects that only focus on data collection, data processing, data analysis, and computational modeling and simulation without direct application to placenta assessment or development of placenta risk indices.
- Basic research and studies of disease mechanisms that are not part of technology advancement or validation.
- Projects directed at understanding placental biology without the advancement or validation of novel technology to assess placental structure or function in real-time.
- Development of technology that has little potential for utility in late first trimester-early second trimester unless the conditions listed below are met.
- Development of projects whose primary focus is on the collection and analysis of imaging or omics data for biomarker identification or validation.
- Development of methods for isolation of placental vesicles or other circulating factors unless done in association with transformative assessment or implementation approaches with high clinical potential.
- Development of methodologies or technologies that are contraindicated for use in human pregnancy.
- Projects in non-mammalian systems that have little potential to be applied to human placenta assessment.
Funding Information
- The combined budget for direct costs for the two year project period may not exceed $275,000. No more than $200,000 may be requested in any single year.
- The scope of the proposed project should determine the project period. The maximum project period is 2 years.
Eligibility Criteria
- Native American tribal governments (Federally recognized)
- Public and State controlled institutions of higher education
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- For profit organizations other than small businesses
- County governments
- Others
- Small businesses
- Special district governments
- Independent school districts
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Public housing authorities/Indian housing authorities
- City or township governments
- Private institutions of higher education
- State governments
For more information, visit Grants.gov.
For more information, visit https://www.grants.gov/web/grants/view-opportunity.html?oppId=343744