Deadline: 13-May-25
The Patient-Centered Outcomes Research Institute is inviting applications for high-quality patient-centered comparative clinical effectiveness research (CER) projects that will address critical decisions faced by patients, families, caregivers, clinicians and the health and healthcare community and for which there is insufficient evidence.
Goal
- The goal of the Phased Large Awards for Comparative Effectiveness Research funding announcement is to support large-scale, high-impact randomized trials in patient centered comparative clinical effectiveness research (CER) whose risk in achieving their research aims merits an initial period of testing and refinement to determine their feasibility and viability and to maximize the likelihood of full-scale trial success.
Priorities
- This funding opportunity seeks applications that address three of PCORI’s National Priorities for Health. To be considered responsive, applicants must propose research that meets this PFA’s distinctive requirements and addresses at least one of the following National Priorities for Health:
- National Priority for Health related to strengthening and expanding CER focused on existing interventions and emerging innovations
- National Priority for Health related to fostering improvements in patient-centered experiences, health care and health outcomes through research supporting a health system to serve the needs and preferences of individuals
- National Priority for Health related to expanding stakeholder engagement, research and dissemination to improve healthcare outcomes for all accounting for variations in disease incidence, prevalence, burden and healthcare practices.
- National Priorities for Health:
- National Priority for Health related to strengthening and expanding CER focused on existing interventions and emerging innovations: Because many patient-centered CER applicants seek to Increase Evidence for Existing Interventions and Emerging Innovations, applicants should consider whether their primary research aim most closely aligns with this as their primary health priority.
- National Priority for Health related to expanding stakeholder engagement, research and dissemination to improve healthcare outcomes for all accounting for variations in disease incidence, prevalence, burden and healthcare practices: Applications that align primarily with this priority focus on overcoming factors that disproportionately affect health outcomes or healthcare delivery in different population groups.
- National Priority for Health related to fostering improvements in patient-centered experiences, health care and health outcomes through research supporting a health system to serve the needs and preferences of individuals: Applications addressing this priority must undertake research that is hypothesis driven and generalizable—and not classifiable as quality improvement.
Funding Information
- Funds Available up to Approximately: $120 million
- Grant amount: $22 million (Feasibility phase maximum: $2 million; Full-scale study phase: $20 million)
- Duration: 6.5 years (Feasibility phase: 1.5 years; Full-scale study phase: 5 years).
Eligibility Criteria
- In general, applications for the conduct of research and management of funding may be submitted by appropriate academic research, private sector research, or study-conducting entities. This may include, among others, agencies and instrumentalities of the federal government, nonprofit and for profit research organizations, and colleges and universities.
- Foreign organizations and nondomestic components of U.S. organizations must provide a thorough and thoughtful justification for the research’s ability to benefit the U.S. healthcare system and that the engagement plans include U.S. patients and stakeholders and are relevant to the U.S. healthcare system.
Ineligibility Criteria
- Individuals are not permitted to apply.
For more information, visit PCORI.