Deadline: 01-Nov-2025
The Angelman Syndrome Alliance has announced its sixth grant call to fund research on Angelman syndrome. This opportunity is open to research teams both in Europe and beyond. The Alliance is dedicated to supporting individuals with Angelman Syndrome, their families, carers, and clinicians. By combining resources and expertise, the ASA aims to advance scientific understanding of Angelman Syndrome and drive progress toward effective treatments.
Research proposals are invited on several suggested topics. These include developing biomarkers to assess target engagement, such as methods to measure brain UBE3A levels using cerebrospinal fluid biomarkers or PET scans. Another focus is on creating objective and quantifiable clinical outcome measures, which may involve wearable devices or other technologies to monitor motor skills, sleep, and seizures in home environments.
Projects examining phenotypes and readouts in human or mouse neurons that reflect UBE3A dysfunction are also encouraged. These studies could help catalog UBE3A variants and investigate the roles of UBE3A regulators and isoforms. There is also interest in mouse model studies that address gaps in preclinical measurements, such as cognitive phenotyping and understanding how UBE3A reinstatement affects phenotypic recovery and brain regions involved.
The maximum funding available is €120,000 for a duration of up to three years. Researchers worldwide are eligible to apply, provided their work focuses on basic science that improves understanding of Angelman Syndrome and contributes toward new treatment development targeting the genetic and molecular causes of the condition.
Applications must include the proposal title, principal investigator’s name and contact information, the investigator’s department, the funding amount requested, project duration, and planned start and end dates. A cover letter, detailed research proposal with goals, methodology, timeline, and budget, a biographical sketch or CV of the investigators, and a lay abstract explaining the project’s aims and potential impact are also required.
For more information, visit Angelman Syndrome Alliance.