Deadline: 8-Dec-21
The Department of Health and Human Services and National Institutes of Health has announced this Funding Opportunity Announcement (FOA) to support a Brazil-US Regional Prospective Observational Research in Tuberculosis (RePORT) network to leverage the robust clinical research infrastructure of Brazil to advance the current understanding of the community, host and microbial factors that impact outcomes of tuberculosis (TB) infection and TB disease, especially among persons with HIV (PWH), including drug-resistant TB, to facilitate the development of tools to improve treatment outcomes at the individual level and to inform strategies to curtail the TB epidemic at the public health level.
Objectives
The primary objective of this initiative is to enable a network of Brazilian and U.S. scientists to advance current understanding of the community, host and microbial factors that impact outcomes of TB infection and TB disease, especially among PWH, including drug-resistant TB (DR-TB), to facilitate development of tools to improve treatment outcomes at the individual level and to inform strategies to curtail the TB epidemic at the public health level.
This bilateral initiative between the United States and Brazil will support a Brazil-US Regional Prospective Observational Research in Tuberculosis (RePORT) network that will leverage the strong clinical research infrastructure within Brazil to facilitate a robust research plan. Research proposed should address TB/HIV priorities of relevance to NIAID and the Brazilian National Plan to End Tuberculosis as a Public Health Problem (Plano Nacional Pelo Fim da Tuberculose como Problema de Saúde Pública) by providing evidence-based strategies towards ending the TB and HIV epidemics. The research outcomes from the projects conducted through the network are also expected to inform Brazil’s national TB control strategy.
The following TB and TB/HIV research areas will be supported:
- Characterization of the risk factors for and molecular epidemiology of DR-TB in Brazil.
- Elucidation of strategies to impact the transmission, incidence, and prevalence of TB in Brazil, including implementation research, or factors that may inform such strategies.
- Development and/or validation of new diagnostics and biomarkers that predict progression to active TB and treatment outcomes of active TB.
- Mechanisms and markers of protection from progression of infection to disease.
- Impact and interactive pathogenesis of TB comorbidities, such as HIV or diabetes.
Research projects that include the following are encouraged:
- Molecular epidemiology of DR-TB in Brazil.
- Development of new diagnostic tests for prognostic biomarkers and/or active and latent TB in conjunction with laboratories and clinical centers in Brazil.
- Research aiming to understand the two-way pathogenesis, impact on clinical outcomes, and associated biomarkers of TB and comorbidities, such as HIV and diabetes.
- Discovery/confirmation of host and microbial factors and mechanisms that affect the risk, dynamics, pathophysiology, and transmission of latent and active TB in children and adults.
- Research towards the continued development of TB vaccines.
- Observational and implementation studies that bridge the knowledge-practice gap in TB diagnosis, treatment, and prevention.
Funding Information
- Funds Available and Anticipated Number of Awards: NIAID intends to commit $1.0 million in FY 2022 to fund 1 award.
- Award Budget: Recommended budget for direct costs of up to $700,000 may be requested.
- Award Project Period: The scope of the proposed project should determine the project period. The maximum project period is 5 years.
Eligibility Criteria
- Higher Education Institutions
- Public/State Controlled Institutions of Higher Education;
- Private Institutions of Higher Education;
- The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
- Hispanic-serving Institutions;
- Historically Black Colleges and Universities (HBCUs);
- Tribally Controlled Colleges and Universities (TCCUs);
- Alaska Native and Native Hawaiian Serving Institutions;
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
- Nonprofits Other Than Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education);
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education);
- For-Profit Organizations
- Small Businesses;
- For-Profit Organizations (Other than Small Businesses).
- Local Governments
- State Governments;
- County Governments;
- City or Township Governments;
- Special District Governments;
- Indian/Native American Tribal Governments (Federally Recognized);
- Indian/Native American Tribal Governments (Other than Federally Recognized).
- Federal Governments
- Eligible Agencies of the Federal Government;
- U.S. Territory or Possession.
- Other
- Independent School Districts;
- Public Housing Authorities/Indian Housing Authorities;
- Native American Tribal Organizations (other than Federally recognized tribal governments);
- Faith-based or Community-based Organizations;
- Regional Organizations;
- Non-domestic (non-U.S.) Entities (Foreign Institutions).
For more information, visit https://www.grants.gov/web/grants/view-opportunity.html?oppId=335144