Deadline: 7-Jul-25
This Grand Challenge on Randomized Controlled Trial on Sexually Transmitted Infections (STIs) and Reproductive Tract Sequelae in Non-Pregnant Women aims to fill critical gaps in understanding of the risk of PID and related sequelae attributable to STIs and to evaluate the impact of etiologic STI screening and treatment on morbidity.
Funding Information
- They will consider applications requesting awards ranging from $8 million to $10 million USD per project, with a grant duration of up to 48 months.
Outcome
- The primary outcome of this study should be PID, with secondary outcomes possibly including chronic pelvic pain, ectopic pregnancy, and infertility.
- The study should provide insight into the risk of outcomes following infection with gonorrhea, chlamydia, and/or trichomoniasis and the impact and cost-effectiveness of etiologic screening to prevent morbidity.
Eligibility Criteria
- This initiative is open to nonprofit organizations, for-profit companies, international organizations, government agencies, and academic institutions.
- Study design must be randomized controlled trial or comparable, robust prospective in Sub-Saharan African settings.
- They encourage groups to build upon existing and/or complimentary projects/studies/trials and to collaborate with other institutions.
- They particularly encourage applications involving projects led by African Primary Investigators (PIs), women, early-career researchers, and practitioners seeking to innovate in women’s health measurement, or from women-led organizations and applications from institutions based in LMICs.
Ineligibility Criteria
- They will not fund proposals that:
- Have trial sites that are not based in sub-Saharan Africa.
- Do not include PID as a primary outcome.
- Include women who are pregnant at baseline.
- Include women with a known diagnosis of infertility at baseline as part of the outcome analysis population.
- Restrict the study population based on HIV status without justification.
- Propose purely observational, retrospective, or modeling-only design.
- Do not address the timing of pathogenesis or provide a strategy for identifying or analyzing the onset of sequelae following STI.
For more information, visit Gates Foundation.