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Home » Department of Health and Human Services/National Institutes of Health: Silencing of HIV-1 Proviruses

Department of Health and Human Services/National Institutes of Health: Silencing of HIV-1 Proviruses

Deadline: 7 December 2016

The National Institutes of Health (NIH), an agency of the Department of Health and Human Services (DHHS) is seeking applications from eligible organisations for a program entitled “Silencing of HIV-1 Proviruses” with an aim to support the identification and optimization of small molecules or RNAs that interact with host epigenetic machinery to mediate long-term or permanent epigenetic silencing of HIV-1 proviruses.

Research Elements

  • Hypothesis-driven target selection in an epigenetic pathway and validation of target(s) where drug or RNA action lead to HIV-1 provirus silencing.
  • The proposal and development of a robust screen that would be useful to identify small molecules or RNAs (i.e. aptamers, x-aptamers, noncoding RNAs) that mediate HIV-1 provirus silencing.
  • The performance of screen(s) and the identification of lead structures.

Award information

  • Application budgets are limited to $500,000 in direct costs per year.
  • The scope of the proposed project should determine the project period.

Eligibility Criteria

  • Higher Education Institutions
    • Public/State Controlled Institutions of Higher Education
    • Private Institutions of Higher Education
    • The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
    • Hispanic-serving Institutions
    • Historically Black Colleges and Universities (HBCUs)
    • Tribally Controlled Colleges and Universities (TCCUs)
    • Alaska Native and Native Hawaiian Serving Institutions
    • Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
  • Nonprofits Other Than Institutions of Higher Education
    • Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
    • Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
  • For-Profit Organizations
    • Small Businesses
    • For-Profit Organizations (Other than Small Businesses)
  • Governments
    • State Governments
    • County Governments
    • City or Township Governments
    • Special District Governments
    • Indian/Native American Tribal Governments (Federally Recognized)
    • Indian/Native American Tribal Governments (Other than Federally Recognized)
    • Eligible Agencies of the Federal Government
    • U.S. Territory or Possession
  • Other
    • Independent School Districts
    • Public Housing Authorities/Indian Housing Authorities
    • Native American Tribal Organizations (other than Federally recognized tribal governments)
    • Faith-based or Community-based Organizations
    • Regional Organizations
    • Non-domestic (non-U.S.) Entities (Foreign Institutions)
  • Foreign Institutions
    • Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.
    • Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.

How to Apply

Applicants must submit their nominations electronically via given website.

For more information, please visit grants.gov.

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