Department of Health and Human Services/National Institutes of Health: Silencing of HIV-1 Proviruses

Deadline: 7 December 2016

The National Institutes of Health (NIH), an agency of the Department of Health and Human Services (DHHS) is seeking applications from eligible organisations for a program entitled “Silencing of HIV-1 Proviruses” with an aim to support the identification and optimization of small molecules or RNAs that interact with host epigenetic machinery to mediate long-term or permanent epigenetic silencing of HIV-1 proviruses.

Research Elements

Hypothesis-driven target selection in an epigenetic pathway and validation of target(s) where drug or RNA action lead to HIV-1 provirus silencing.
The proposal and development of a robust screen that would be useful to identify small molecules or RNAs (i.e. aptamers, x-aptamers, noncoding RNAs) that mediate HIV-1 provirus silencing.
The performance of screen(s) and the identification of lead structures.

Award information

Application budgets are limited to $500,000 in direct costs per year.
The scope of the proposed project should determine the project period.

Eligibility Criteria

Higher Education Institutions
- Public/State Controlled Institutions of Higher Education
- Private Institutions of Higher Education
- The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
Nonprofits Other Than Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
For-Profit Organizations
- Small Businesses
- For-Profit Organizations (Other than Small Businesses)
Governments
- State Governments
- County Governments
- City or Township Governments
- Special District Governments
- Indian/Native American Tribal Governments (Federally Recognized)
- Indian/Native American Tribal Governments (Other than Federally Recognized)
- Eligible Agencies of the Federal Government
- U.S. Territory or Possession
Other
- Independent School Districts
- Public Housing Authorities/Indian Housing Authorities
- Native American Tribal Organizations (other than Federally recognized tribal governments)
- Faith-based or Community-based Organizations
- Regional Organizations
- Non-domestic (non-U.S.) Entities (Foreign Institutions)
Foreign Institutions
- Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.
- Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.

How to Apply

Applicants must submit their nominations electronically via given website.

For more information, please visit grants.gov.