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National Institutes of Health: Target Assessment, Engagement and Data Replicability

Deadline: 7 September 2019

The National Institutes of Health (NIH), an agency of the Department of Health and Human Services (DHHS) is seeking applications from eligible organisations for a program entitled “Target Assessment, Engagement and Data Replicability to Improve Substance Use Disorders Treatment Outcomes”.

It encourages applications that focus on early-stage, treatment generation and pilot clinical trials that are consistent with an experimental therapeutic approach. This approach requires the identification of a theory-derived target based on putative mechanisms of alcohol, tobacco and other drug use, and clear hypotheses about how a treatment directed at changing the target can lead to clinical benefits.

Funding Information

  • The 2-year R21 phase may not exceed $275,000 in direct costs, with no more than $200,000 in direct costs in any single year. The R33 phase budgets are not limited but need to reflect the actual needs of the proposed project.
  • The maximum project period is 5 years; 2 years for the R21 phase and 3 years for the R33 phase.

Project Priorities

  • Applicants are strongly encouraged to propose projects related to multiple substances, which may include poly-substance use or abuse. Consistent with the overall goals of the CRAN initiative, such projects will receive programmatic priority over projects focused on a single substance.
  • Applications should address a theoretical rationale for relevant treatment targets to understand the treatment of substance use, and the hypothesized ways in which these target mechanisms are modulated throughout the course of treatment.
  • While the testing of targeted treatments may be done in randomized clinical trials, other methodologies may be used as appropriate (e.g., adaptive designs, multiphase optimization strategies, stepped wedge designs).

Eligibility Criteria

  • Higher Education Institutions
    • Public/State Controlled Institutions of Higher Education
    • Private Institutions of Higher Education
  • Nonprofits Other Than Institutions of Higher Education
    • Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
    • Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
  • For-Profit Organizations
    • Small Businesses
    • For-Profit Organizations (Other than Small Businesses)
  • Governments
    • State Governments
    • County Governments
    • City or Township Governments
    • Special District Governments
    • Indian/Native American Tribal Governments (Federally Recognized)
    • Indian/Native American Tribal Governments (Other than Federally Recognized)
    • Eligible Agencies of the Federal Government
    • U.S. Territory or Possession
  • Other
    • Independent School Districts
    • Public Housing Authorities/Indian Housing Authorities
    • Native American Tribal Organizations (other than Federally recognized tribal governments)
    • Faith-based or Community-based Organizations
    • Regional Organizations
    • Non-domestic (non-U.S.) Entities (Foreign Institutions)
  • Foreign Institutions
    • Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.
    • Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.
    • Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

How to Apply

Interested applicants must submit their applications electronically via given website.

For more information, please visit grants.gov.