Deadline: 16 February 2017
amfAR, The Foundation for AIDS Research is inviting applicants for its Innovation Grants to fund research that explores all curative approaches, including reservoir removal, elimination of mechanisms that sustain the reservoir, editing the provirus sufficiently to render it benign, or suppressing the intact provirus, thus preventing pathogenicity.
Areas of Interest
- Clinical proof of concept: Treatments currently approved for use in humans could have value in eliminating or disabling the viral reservoir in HIV-infected individuals and may permanently prevent viral rebound in the absence of ART. Clinical proof-of-concept studies are expected to enroll a circumscribed number of HIV-positive individuals to test the intervention, use historical controls, and measure endpoints that predict cure or remission.
- Approaches that lead to disabling or eradicating the HIV reservoir: Research proposing novel mechanisms or substantially improved approaches to eradicating or permanently disabling the reservoir cells or the provirus are needed. Screens for latency-reversing agents will be considered low priority.
- Mechanisms that drive HIV reservoir persistence: Research aimed at discovering and targeting novel mechanisms that maintain the viral reservoir are needed. Research is expected to define, for example, novel and targetable signaling mechanisms that maintain the reservoir. Studies aimed at simply describing mechanisms of persistence are of extremely low priority.
Grant Information
Innovation Grants provide funding of up to $200,000 (including indirect costs at a maximum rate of 20%) over a two-year performance period beginning on July 1, 2017.
Eligibility Criteria
- Institutions: Applications, if invited, are accepted from nonprofit research institutions worldwide; applications are not accepted from individuals or for-profit entities. However, although the Principal Investigator must be from the applicant institution, research teams may include members from, and budgets may include subcontracts or sub awards to, for-profit entities.
- Principal Investigators:
- Must hold a doctoral level degree
- Must be affiliated with the applicant institution
- If the proposal is a collaboration including subcomponent projects, the Principal Investigator will be expected to lead one of the component projects, coordinate the development, implementation and analysis of the projects as a whole, and be responsible for overall financial management and the preparation and submission of required reports.
How to Apply
Interested applicants must apply online via given website.
For more information, please visit Innovation Grants.