ReadCoor Receives Grant from Chan Zuckerberg Initiative

ReadCoor, Inc., a company reinventing omics and pathology with its panomic spatial sequencing platform, announced a grant from the Chan Zuckerberg Initiative (CZI) and DAF, an advised fund of Silicon Valley Community Foundation, to spatially map cortical cells using Fluorescent in situ Sequencing (FISSEQ) for the Human Cell Atlas.

The collaboration’s goal is to benchmark in situ technologies and establish best practices for the Human Cell Atlas.  The atlas will contain in depth variance maps of cell transcriptomes, genomes, proteomes, metabolomes, and epigenetic landscapes.  FISSEQ will provide deep insight into cell variation in the context of the tissue micro environment, a feature that is difficult or impossible to obtain with traditional in situ methods.

FISSEQ also uniquely delivers researchers an opportunity to locate genes that have mutated away from the original sequence due to its ability to produce reads without known gene targets. Most standard in situ methods are blind to such changes and can miss altered genes.

The research project is part of an Allen Institute-led consortium of world-class research institutions. Members include the Allen Institute for Brain Science (Ed Lein and Hongkui Zeng), Broad Institute (Aviv Regev, Evan Macosko and Fei Chen), California Institute of Technology (Long Cai and Barbara Wold), Cold Spring Harbor Laboratory (Anthony Zador), Harvard University (George Church, Paola Arlotta and Xiaowei Zhuang), Karolinska Institute (Sten Linnarsson), KTH Royal Institute of Technology (Joakim Lundeberg), Massachusetts Institute of Technology (Ed Boyden), Stockholm University (Mats Nilsson), and the University of California, San Diego (Kun Zhang). The ReadCoor team is led by Samuel A. Inverso.

FISSEQ is a spatial sequencing technology that reads and visualizes the three-dimensional coordinates of molecules of intact tissue, a capability that stands to revolutionize panomics and pathology. FISSEQ was developed in the Church Lab at Harvard University and the Wyss Institute for Biologically Inspired Engineering, and first published in Science in 2014 (Highly multiplexed three-dimensional subcellular transcriptome sequencing in situ).

ReadCoor is leading the next generation of omics by delivering the first panomic spatial sequencing platform to the global audience of researchers, clinicians, pharma and diagnostics companies, and ultimately patients. It is accomplishing this with Fluorescent in situ Sequencing (FISSEQ), a fundamental new technology, which simultaneously integrates high-throughput sequencing, and three-dimensional morphometric analysis. This uniquely powerful platform is expected to revolutionize the next phase in understanding the panomic landscape and introduce vast new opportunities for important and meaningful clinical insight.

The Chan Zuckerberg Initiative was launched in December 2015 by Mark Zuckerberg, founder and CEO of Facebook, and his wife, Priscilla Chan, a pediatrician and founder and CEO of The Primary School in East Palo Alto. The Chan Zuckerberg Initiative is a new kind of philanthropic organization dedicated to advancing human potential and promoting equal opportunity through world class engineering, grantmaking, impact investing, policy, and advocacy work.

U.S. Department of Justice, OVW: Grants to Enhance Culturally Specific Services for Victims of Sexual Assault, Domestic Violence, Dating Violence and Stalking Program

Righteous Persons Foundations: Supporting Jewish Community in United States

EU Call for Proposals: Enhancing CSOs’ Contribution to Governance and Development Process in Vietnam

Rise Against Hunger: Seeking Applications for Nourishing Lives Partnership (NLP) Program

Apply for Russell Sage Foundation’s Grant Program!

U.S. Department of State: Countering Violent Extremism in the Philippines through Targeted, Networked, and Effective Initiatives

3ie Request for Proposals: Qualitative Evaluation of the Impact of Self-Help Groups on Women’s Economic and Social Empowerment in India

Global Affairs Canada Call for Proposals: Dismantling Barriers & Improving the Quality of Education for Women and Girls

National Geographic Society: Documenting Human Migrations Program

Embassy of the Netherlands in Turkey: Seeking Proposals for Matra Programme

U.S. Department of State, Bureau of INL: Eastern Caribbean Organized Crime Investigation Program

Call for Applications: Sky Ranch Foundation’s Grant Program

Embassy of the Netherlands: Inviting Turkish Organisations for Human Rights Fund

U.S. Department of Justice: 2019 Sexual Assault Services Culturally Specific Program

2019 Resist Grant: Supporting People’s Movements for Justice and Liberation in U.S.

IOOF Foundation’s Grant: Inviting Applicants from Australia

GCERF Call for Concept Notes: Strengthening Community Resilience to Violent Extremism in Tunisia

U.S. Mission to Bosnia and Herzegovina: Seeking Applications for Interethnic Reconciliation and Youth Program

Canadian Women’s Foundation: Seeking Proposals for Annual Violence Prevention Grants 2019

National Endowment for the Arts: Seeking Applications for Challenge America Grants Program

NEA: Seeking Applications for “NEA Art Works 1” Grants Program

CMA CGM Foundation 2019 Call for Proposals: Promoting Access to Education for Children in Difficulty

British Council: Inviting Applicants for Sub-Saharan Africa Research Grants

EU-Paraguay Call for Proposals: 2018-2019 European Instrument for Democracy and Human Rights (EIDHR) Country Support Scheme

>