NCI: Metabolic Dysregulation and Cancer Risk Program – US

Deadline: 01-Sep-21

The National Cancer Institute (NCI) invites research grant proposals for transdisciplinary studies that will enhance their knowledge of the dynamics and underlying mechanisms that link obesity, metabolic dysregulation and increased cancer risk.

Through this Funding Opportunity Announcement (FOA), the Metabolic Dysregulation and Cancer Risk Program will focus on metabolic dysregulation as the key process linking obesity with cancer risk.

For the purpose of this FOA, metabolic dysregulation is defined as alterations in glucose utilization and storage, insulin sensitivity, and/or lipid metabolism.

Goals

The short-term scientific goals of the Metabolic Dysregulation and Cancer Risk Program include:

• understand the mechanisms by which obesity-related metabolic dysregulation (defined as alterations in glucose utilization and storage, insulin sensitivity, and/or lipid metabolism) affect cancer initiation and development;
• develop common measures for obesity-related metabolic dysregulation across specific cancer types;
• define critical signal pathways between biologic processes (e.g., insulin resistance and inflammation) that regulate obesity-associated metabolic alterations and cancer risk;
• determine the utility of emerging approaches for the discovery of novel obesity-associated metabolic targets in cancer risk and prevention.

Objectives

• Applicants responding to this FOA are strongly advised to review all components of this FOA for specific guidance and requirements, including:
  • Familiarize themselves with the companion FOA for the Coordinating Center to avoid duplicative allocation of budget for services (i.e. biostatistical needs) provided by the Coordinating Center. As the U01 awardees will interact closely with the Coordinating Center, the applicants responding to this FOA, therefore, need to understand the role and responsibilities of the Coordinating Center.
  • Understand the required participation in cross-Consortium activities as part of Metabolic Dysregulation and Cancer Risk Program.
  • Share de-identified data and metadata to a controlled-access data repository when appropriate, either an NIH data repository or repository with equivalent access. If applicable, investigators are expected to evaluate and document compliance with NCI’s Best Practices for Biospecimen Resources for the collection, processing, and storage of biospecimen.

• Individual research project grants should address one or more of the following main research objectives:
  • Investigate molecular mechanisms that define how metabolic dysregulation impacts obesity-associated cancer risk;
  • Characterize an altered metabolic profile (e.g., metabolic-related markers) that identifies at-risk individuals;
  • Test interventions designed to modify obesity-associated metabolic pathways to decrease cancer risk.

Funding Information

• Application budgets may not exceed $850,000 in direct costs per year (excluding sub-award F&A costs) and must reflect the actual needs of the proposed project.
• Total project period may not exceed 5 years.

Eligibility Criteria

• Higher Education Institutions
  • Public/State Controlled Institutions of Higher Education
  • Private Institutions of Higher Education
• The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
  • Hispanic-serving Institutions
  • Historically Black Colleges and Universities (HBCUs)
  • Tribally Controlled Colleges and Universities (TCCUs)
  • Alaska Native and Native Hawaiian Serving Institutions
  • Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
• Nonprofits Other Than Institutions of Higher Education
  • Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
  • Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
• For-Profit Organizations
  • Small Businesses
  • For-Profit Organizations (Other than Small Businesses)
• Local Governments
  • State Governments
  • County Governments
  • City or Township Governments
  • Special District Governments
  • Indian/Native American Tribal Governments (Federally Recognized)
  • Indian/Native American Tribal Governments (Other than Federally Recognized)
• Federal Governments
  • U.S. Territory or Possession
• Other
  • Independent School Districts
  • Public Housing Authorities/Indian Housing Authorities
  • Native American Tribal Organizations (other than Federally recognized tribal governments)
  • Faith-based or Community-based Organizations
  • Regional Organizations

For more information, visit https://www.grants.gov/web/grants/view-opportunity.html?oppId=334577