Deadline: 14-Oct-22
The National Institutes of Health (NIH) invites clinical research applications that are exploratory/developmental in nature, and seek to parse the complex effects of structural racism, and investigate its impact on neurocognition, with an emphasis on reducing Substance Use Disorder (SUD) risk and informing preventative interventions.
Topics
Topics of interest include, but are not limited to:
- Development and application of assessment tools towards capturing multidimensional socio-environmental influences that minimize participant burden and increase inclusion of underserved racial and ethnic minority groups
- Application of sophisticated analytical methods to investigate multivariate and/or non-linear relationships within large, complex socio-environmental datasets (e.g., testing non-linear dynamics involving structural factors and individual characteristics)
- Identification of novel mediating pathways linking the experience of structural inequities and racism (including effects of stigmatization and discrimination) to neurocognition pertaining to SUD risk (e.g., brain-gut interactions, CNS-immune and CNS-endocrine system interactions, epigenetic modifications)
- Secondary analysis of large longitudinal datasets (e.g., Adolescent Brain Cognitive DevelopmentSM(ABCD), HEALthy Brain and Child Development (HBCD)) to examine causal pathways between exposure to structural racism and psychophysiological or neurobiological risks that may affect the onset or course of substance use
- Identification of the neurocognitive mechanisms through which protective factors (e.g., support from and connections with racial and ethnic minority community) moderate the influence of racism, specifically those that could inform development of novel interventions
- Investigation of the neurocognitive effects of structural or interpersonal interventions designed to address the impacts of racism
- Development of novel interventions targeting the neurocognitive level that modulate behavior and/or cognition relevant to the intersection of SUD and racism
Funding Information
- For the R61 planning phase, the combined budget for direct costs for up to two years may not exceed $500,000.
- For the R33 phase, the budget for direct costs may not exceed $500,000 in any single year.
- The maximum period of the combined R61 and R33 phases is 5 years, with up to 2 years for the R61 phase and up to 3 years for the R33 phase. The scope of the proposed project should determine the requested project period.
Eligibility Criteria
- Public housing authorities/Indian housing authorities
- Others
- Private institutions of higher education
- Independent school districts
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Small businesses
- Special district governments
- Native American tribal organizations (other than Federally recognized tribal governments)
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- State governments
- Native American tribal governments (Federally recognized)
- City or township governments
- For profit organizations other than small businesses
- Public and State controlled institutions of higher education
- County governments
For more information, visit https://www.grants.gov/web/grants/view-opportunity.html?oppId=343045
