Deadline: 23-Sep-2025
The Patient-Centered Outcomes Research Institute is inviting innovative proposals through its Cycle 3 2025 initiative aimed at advancing the methods that underpin patient-centered comparative clinical effectiveness research.
Investigators are invited to address crucial methodological gaps—whether through advancing artificial intelligence and machine learning in research, refining study designs, supporting data-focused research networks, or enhancing ethical and human subjects protections across the research lifecycle.
This opportunity is structured to push beyond traditional clinical trials and encourage innovative methodological tools that enhance the rigor, reliability, and relevance of CER. Whether the goal is to build smarter statistical approaches or to create frameworks that safeguard participants while deepening scientific insight, the venue is open for practical, scalable solutions with real-world impact.
PCORI emphasizes meaningful engagement across all funded projects, asking teams to thoughtfully integrate patient and stakeholder perspectives in line with its “Foundational Expectations for Partnerships in Research.” This reflects PCORI’s longstanding commitment to research that is not only scientifically sound but also rooted in the lived experience of those most affected.
Funding for this opportunity is substantial and precise. The maximum project budget is $750,000 in direct costs, with a maximum research project period of up to three years. These parameters are designed to support projects that are both ambitious and feasible, ensuring that funded work can produce meaningful advances in methodology within a defined timeframe.
Eligibility is open to a wide range of organizations capable of conducting rigorous research and managing significant funding. Applications may be submitted by academic research institutions, private sector research groups, or other study-conducting entities. This includes agencies and instrumentalities of the federal government, nonprofit and for-profit research organizations, and colleges and universities. The broad scope of eligibility ensures that diverse expertise and institutional strengths can contribute to advancing the science of CER.
This call offers a rare and timely chance for methodological innovators to sharpen the tools of CER and set new standards for evidence generation, ultimately improving health decisions and outcomes across diverse clinical and community settings.
For more information, visit PCORI.
