Deadline: 2 November 2016
The National Institutes of Health is currently seeking proposals from eligible organisations for its program- Systems Approach to Immunity and Inflammation. the aim of the program is to develop a comprehensive understanding of innate and adaptive immune responses triggered by pathogens, adjuvants, or vaccines.
The long-range goal of this program is to advance our understanding of immune response dynamics following infection with a pathogen or administration of an adjuvant or vaccine; and to provide foundational information that can be applied to the development of novel translational approaches for production of vaccines or immune-based therapeutics.
Areas of Interest
Examples of research areas of interest include, but are not limited to:
- Determination of the functions of novel immune genes and/or proteins that are triggered in the primary or secondary response to infectious pathogens, adjuvants, or vaccines.
- Identification of new functions for known genes/proteins in regulating or contributing to the generation and maintenance of protective or pathogenic immunity in response to infectious pathogens, adjuvants, or vaccines.
- Dissection of the molecules and pathways involved in the regulation of the innate and/or adaptive immune system.
- Determination of the mechanisms that regulate antibody production to pathogens, such as heavy chain class switching, affinity maturation/somatic hypermutation, plasma cell generation and maintenance, and cellular mechanisms required for generation of protective antibody responses.
- Regulation of mucosal immunity triggered in response to infectious pathogens, adjuvants or vaccines.
- Determination of the mechanisms of transcriptional or translational regulation of the innate or adaptive immune system, including, but not limited to the role of MicroRNA or Long non-coding RNA in regulating immune responses to pathogens, vaccines or adjuvants.
- Understanding genomic regulation of immune response genes (e.g., epigenetic, enhancer accessibility/occupancy, structural and spatial organization of chromosomes) and the impact on immunity to pathogens, vaccines, or adjuvants.
- Understanding the interacting cell types and spatial/temporal relationships during immune responses to pathogens, vaccines, or adjuvants.
- Identifying the signal transduction mechanisms and/or networks activated in cells of the innate or adaptive immune system in response to pathogens, vaccines, or adjuvants.
The maximum project period is five years.
- The budget for each application cannot exceed $1,500,000.
- The direct costs per award, per year, lies between $100,000 (minimum) to $200,000 (maximum) for years 2-5 for the Pilot Project Program.
- Native American tribal governments (Federally recognized)
- City or township governments
- County governments
- State governments
- Others (see text field entitled “Additional Information on Eligibility” for clarification)
- Small businesses
- For profit organizations other than small businesses
- Public and State controlled institutions of higher education
- Public housing authorities/Indian housing authorities
- Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- Independent school districts
- Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- Special district governments
- Native American tribal organizations (other than Federally recognized tribal governments)
- Private institutions of higher education
Other Eligible Applicants include the following:
- Alaska Native and Native Hawaiian Serving Institutions;
- Asian American Native American Pacific Islander Serving Institutions (AANAPISISs);
- Eligible Agencies of the Federal Government;
- Faith-based or Community-based Organizations;
- Hispanic-serving Institutions;
- Historically Black Colleges and Universities (HBCUs);
- Indian/Native American Tribal Governments (Other than Federally Recognized);
- Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations;
- Tribally Controlled Colleges and Universities (TCCUs) ;
- S. Territory or Possession;
- Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
How to Apply
Applicants can apply via given website.
Eligible Country: United States
For more information, please visit grants.gov.