DHHS/NIH: Exploiting HIV and Host Genomic Information to Understand HIV Compartments or Reactivation in Individuals with Substance Use Disorders

Deadline: 13 December 2017

The U.S Department of Health and Human Services (DHHS), National Institutes of Health (NIH) is seeking proposals for funding a opportunity entitled “Exploiting HIV and Host Genomic Information to Understand HIV Compartments or Reactivation in Individuals with Substance Use Disorders”. This initiative will support exploratory projects that exploit HIV or host genomic or nucleomic information to understand HIV latency in individuals with substance use disorders (SUDs).

Focus Components

Proposed projects must include the following three components. Applications which lack any of these three components will be considered non-responsive to the FOA and will not be reviewed.

The major thrust of the project must involve exploitation of HIV or host genomic or nucleomic information to understand HIV latency or reservoirs.
Applicants MUST propose studies that investigate biological samples or post-mortem tissues from human patients or primates. Primary cells, cell lines, organoids, or other systems may be proposed for ancillary investigations, if appropriately justified.
At least one aim or sub-aim must also involve either:
- opioid, cannabinoid, nicotinic, dopaminergic, or other signaling pathways relevant to addictive substance use,
- exposure to addictive substances,
- Analysis of samples from patients that have used addictive substances or have SUDs. Addictive substances of interest include: nicotine, cocaine, stimulants, opioids, prescription drugs, cannabinoids, alcohol, or combinations of these drugs. Applications focused solely on alcohol exposure must not be submitted to this FOA.

Funding Information

Application budgets are limited to $650,000 direct costs and must reflect the actual needs of the proposed project.

Eligibility Criteria

Native American tribal organizations (other than Federally recognized tribal governments)
For profit organizations other than small businesses
Native American tribal governments (Federally recognized)
Public housing authorities/Indian housing authorities
County governments
Special district governments
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
City or township governments
Public and State controlled institutions of higher education
State governments
Small businesses
Independent school districts
Others (see text field entitled “Additional Information on Eligibility” for clarification)
Private institutions of higher education
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education