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Call for Proposals: Operational Research on Resistance New Projects

Deadline: 21-Jan-2025

This call invites proposals seeking initial funding from L’Initiative (new projects) to support innovative operational research for improving the prevention, diagnosis, and effective management of resistance.

Priority Areas
  • The following priority areas:
    • Strengthening resistance monitoring:
      • Improve data collection on the ground and information systems at national level, to increase the speed of the response of national programs where resistance occurs and demonstrate the relevance and effectiveness of community involvement.
      • Study the impact of population displacement on the spread of resistant strains and develop transnational strategies to monitor and control resistance in contexts where there are mobile populations.
    • Improving prevention, early diagnosis and adequate management of resistance       
      • Strengthen the capacity of health professionals including health workers in outpatient departments, local health facilities and the community to diagnose resistance and provide the relevant care. More specifically, propose community approaches to prevent resistance and for adherence to treatment regimens, including information provision and mobilizing communities around resistance and community-based distribution of medications.
      • Develop and make available rapid, affordable and accurate diagnostic tests to detect resistance, including in decentralized contexts.
      • In terms of malaria, assess approaches to diversify treatment combinations to reduce the genetic pressure on the most commonly used regimens and extend their lifespan.
      • In terms of HIV, propose data-driven surveillance systems; develop adherence optimization approaches to stop the emergence of resistance and also identify those who are at highest risk of developing resistance to focus interventions on these groups.
      • In terms of TB, assess the acceptability and feasibility of shorter treatment regimens for people affected by MDR-TB.
    • Modeling resistance and developing evolution scenarios: 
      • Use epidemiological modelling to anticipate how resistance in the three diseases will evolve.
      • Assess the long-term impacts of current interventions to reduce resistance.
Funding Information
  • The total requested grant amount must cover at least 50% of the project budget and be between €650,000 and €3,500,000.
Duration
  • Project duration must be between 36 and 48 months.
Eligibility Criteria
  • It must be submitted by a lead applicant, in collaboration with “implementing partners” or “associate stakeholders”:
    • The “lead applicant” is the organization that submits the letter of intent and completes the full proposal if they are pre-selected. Lead applicants are the sole recipients of L’Initiative grants and shall be individually responsible vis-à-vis Expertise France for implementation of the Project.
    • The project lead applicant must be legally registered and have a board of Directors/management committee and a registered headquarters in an eligible country or in France. International organizations, with the exception of regional non-state organizations, may not be the lead applicant or an implementing partner of projects. However, they can be associated stakeholders that do not receive any delegated budget.
    • The lead applicant must have been legally registered for at least 3 years at the time of project submission.
  • Be implemented in one or more of the 38 eligible countries listed below:
    • Algeria, Benin, Burundi, Cambodia, Cameroon, Central African Republic, Chad, Comoros, Congo, Ivory Coast, Democratic Republic of the Congo, Dominican Republic, Djibouti, Equatorial Guinea, Ethiopia, Gabon, Gambia, Ghana, Guinea, Guinea-Bissau, Haiti, Laos, Lebanon, Liberia, Madagascar, Morocco, Mauritius, Mauritania, Mozambique, Myanmar, Rwanda, Senegal, Sierra, Leone, Thailand, Togo, Tunisia, Ukraine, Vietnam.

For more information, visit L’Initiative.