The Department of Health and Human Services, National Institutes of Health (NIH) is seeking applications to support the development and evaluation of tobacco cessation interventions tailored to HIV-positive populations, including those with comorbidities such as TB, in low-resource settings in low- and middle-income countries (LMICs).
In particular, this FOA aims to bring together transdisciplinary teams of investigators to adapt interventions developed and tested in other challenging settings or low-resource populations and to test their robustness among persons living with HIV (PLWH) in LMICs. The long-term goal is to reduce tobacco use rates among PLWH in LMICs, and thus tobacco-related morbidity and mortality in this population.
Responsive applications should address High Priority topics of research identified in the NIH HIV/AIDS Research Priorities and Guidelines for Determining AIDS Funding which include research to reduce HIV-associated comorbidities (e.g., cancer) and research to reduce health disparities in the treatment outcomes of PLWH.
Specific Research Objectives
This FOA aims to support a cohort of U01 grants focused on addressing tobacco use among PLWH in LMICs. The primary aim of the FOA is to support the development and evaluation of tobacco cessation interventions tailored to HIV-positive populations, including those with comorbidities such as TB, in LMICs. Specific primary research questions to be addressed include, but are not limited to, the following:
- What types of tobacco cessation interventions are most effective in PLWH in LMICs to achieve improved tobacco abstinence as well as HIV-related treatment outcomes?
- How can evidence-based smoking cessation interventions be adapted to improve smoking cessation outcomes among PLWH in LMICs?
- How can the robustness and translatability of interventions from challenging or low-resource settings (e.g. persons with substance abuse or mental health comorbidities) be evaluated in the context of PLWH in LMICs?
- What innovative but previously tested strategies can be scaled-up for PLWH in LMICs, including use of community health services, mobile technology, and behavioral counseling?
Additional topics (e.g., secondary research questions) that fall within the scope of this FOA include, but are not limited to the following:
- What are the barriers to integrating tobacco control interventions into the existing HIV prevention and treatment context in LMICs? How can they be surmounted?
- What is the cost-effectiveness of integrating smoking cessation within HIV treatment?
- How does the social and behavioral context of tobacco use in PLWH in LMICs, including the use and abuse of other substances, influence tobacco use behavior and cessation outcomes?
- How does the use or co-use of other tobacco products (e.g., electronic nicotine delivery systems [ENDs], hookah smoking, smokeless tobacco) impact cessation behavior as well as HIV progression and treatment outcomes?
- How does smoking impact adherence to treatment among patients with HIV, including those with TB or other comorbidities?
- Higher Education Institutions
- Public/State Controlled Institutions of Higher Education
- Private Institutions of Higher Education
- The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
- Nonprofits Other Than Institutions of Higher Education
- Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
- For-Profit Organizations
- Small Businesses
- For-Profit Organizations (Other than Small Businesses)
- Local Governments
- State Governments
- County Governments
- City or Township Governments
- Special District Governments
- Indian/Native American Tribal Governments (Federally Recognized)
- Indian/Native American Tribal Governments (Other than Federally Recognized)
- Federal Governments
- Eligible Agencies of the Federal Government
- U.S. Territory or Possession
- Foreign Institutions
- Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.
- Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.
- Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
For more information, visit https://www.grants.gov/web/grants/view-opportunity.html?oppId=328022